Demystifying Mechanosensitive Piezo Ion Channels
نویسندگان
چکیده
منابع مشابه
Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels
Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our finding of the miniature pore-forming module of Piezo1 that resembles the pore arc...
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Mechanosensory transduction underlies touch, hearing and proprioception and requires mechanosensitive channels that are directly gated by forces; however, the molecular identities of these channels remain largely elusive. A new study has identified Piezo1 and Piezo2 as a novel class of mechanosensitive channels.
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Cell surface receptors are involved in numerous important biological processes including embryogenesis, tissue differentiation, and cellular homeostasis. Among them, mechanosensitive ion channels play an essential role in cellular functions of every cell including neurons, cardiomyocytes, and osteocytes. Here, we discuss types, roles, structures, and biophysical factors that affect the function...
متن کاملMechanosensitive ion channels
Mechanosensitive (MS) ion channels are to date the best characterized biological force-sensing systems. They present the best example of coupling protein conformations to the mechanics of the surrounding cell membrane. Studies of MS channels conducted over the last 28 years have from their serendipitous discovery and confusion about their artifactual nature to their molecular identification and...
متن کاملGsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels.
GsMTx4 is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs). It has six lysine residues that have been proposed to affect membrane binding. We synthesized six analogs with single lysine-to-glutamate substitutions and tested them against Piezo1 channels in outside-out patches and independently measured lipid binding. Four analogs had ∼20% lower efficacy than the wild...
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ژورنال
عنوان ژورنال: Neuroscience Bulletin
سال: 2016
ISSN: 1673-7067,1995-8218
DOI: 10.1007/s12264-016-0033-x